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Volume 3 Supplement 2

21st European Workshop for Rheumatology Research

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The shared epitope revisited: shared epitope negative HLA-DR alleles influence susceptibility to rheumatoid arthritis

Arthritis Research & Therapy volume 3, Article number: P103 (2001) Cite this article

We propose to classify HLA-DRB1 alleles into 3 groups: shared epitope positive (SE), shared epitope negative with a positively charged HLA-DR P4 pocket (XP4p) and shared epitope negative with a negative or neutral HLA-DR XP4 pocket (XP4n). Using this classification to analyse 3 different French populations, we find that:

-SE/SE or SE/XP4p genotypes are associated with a high risk to develop RA.

-XP4p/XP4p or SE/XP4n genotypes are neutral

-XP4p/XP4p or XP4n/XP4n genotypes are protective with respect to the development of RA.

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Authors and Affiliations

  1. INSERM EMI9940, Rheumatology Ward La Conception and EFS Histocompatibility, Marseille, France

    D Reviron, A Perdriger, E Toussirot, D Wendling, N Balandraud, S Guis, G Semana, P Tiberghien, P Mercier & J Roudier

  2. Rheumatology Ward and EFS Histocompatibility Rennes, France

    D Reviron, A Perdriger, E Toussirot, D Wendling, N Balandraud, S Guis, G Semana, P Tiberghien, P Mercier & J Roudier

  3. Rheumatology Ward and EFS Histocompatibility, Besançon, France

    D Reviron, A Perdriger, E Toussirot, D Wendling, N Balandraud, S Guis, G Semana, P Tiberghien, P Mercier & J Roudier

Authors
  1. D Reviron
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  2. A Perdriger
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  3. E Toussirot
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  4. D Wendling
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  5. N Balandraud
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  6. S Guis
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  7. G Semana
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  8. P Tiberghien
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  9. P Mercier
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  10. J Roudier
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Reviron, D., Perdriger, A., Toussirot, E. et al. The shared epitope revisited: shared epitope negative HLA-DR alleles influence susceptibility to rheumatoid arthritis. Arthritis Res Ther 3 (Suppl 2), P103 (2001). https://doi.org/10.1186/ar272

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  • DOI: https://doi.org/10.1186/ar272

Keywords

Arthritis Research & Therapy

ISSN: 1478-6362

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