From: Synovial fluid level of aggrecan ARGS fragments is a more sensitive marker of joint disease than glycosaminoglycan or aggrecan levels: a cross-sectional study
Assay
Cut-off
AUC
Sensitivity
Specificity
OA-1 ARGS ELISA
1 pmol ARGS/ml
82%
67%
92%
Alcian blue precipitation
88.5 μg sGAG/ml
63%
40%
1-F21 ELISA
188.5 μg aggrecan/ml
53%
32%
91%
ARGS/sGAG*
5%
83%
65%
96%