TY - JOUR AU - Zheng, Hui AU - Chen, Yi AU - Ao, Wen AU - Shen, Yan AU - Chen, Xiao-wei AU - Dai, Min AU - Wang, Xiao-dong AU - Yan, Yu-cheng AU - Yang, Cheng-de PY - 2009 DA - 2009/06/22 TI - Antiphospholipid antibody profiles in lupus nephritis with glomerular microthrombosis: a prospective study of 124 cases JO - Arthritis Research & Therapy SP - R93 VL - 11 IS - 3 AB - Glomerular microthrombosis (GMT) is a common vascular change in patients with lupus nephritis (LN). The mechanism underlying GMT is largely unknown. Although several studies have reported the association of antiphospholipid antibodies (aPL) with GMT, the relation between GMT and aPL remains controversial. Previous studies have demonstrated that some aPL could bind to several hemostatic and fibrinolytic proteases that share homologous enzymatic domains. Of the protease-reactive aPL, some can inhibit the anticoagulant activity of activated protein C and the fibrinolytic function of plasmin, and hinder the antithrombin inactivation of thrombin. The purpose of this study was to investigate the prevalence of GMT in LN patients and examine the relation between the aPL profiles (including some protease-reactive aPL) and GMT. SN - 1478-6354 UR - https://doi.org/10.1186/ar2736 DO - 10.1186/ar2736 ID - Zheng2009 ER -