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Table 1 Demographic, clinical, and laboratory characteristics of the LN patients*

From: Antiphospholipid antibody profiles in lupus nephritis with glomerular microthrombosis: a prospective study of 124 cases

  LN-GMT
(n = 25)
LN-non-GMT
(n = 99)
P value
Sex (male/female) 3/22 16/83 0.837
Age (years) 35 ± 14 33 ± 14 0.485
SLE duration (months) 48 (8 to 126) 19 (4 to 69.5) 0.096
LN duration (months) 19 (1 to 78) 4.5 (1–24) 0.101
SLEDAI 17 ± 6 12 ± 6 0.002
Proteinuria (g/24 hours) 3.24 (2.22 to 4.66) 2.01 (1.19 to 3.66) 0.005
Serum creatinine (μmol/L) 99.7(67.85 to 118.5) 59.6(49.08 to 82.75) <0.001
Blood urea nitrogen (mmol/L) 11.3 (6.05 to 15) 6.4 (4.9 to 10) 0.007
Serum C3 (g/L) 0.44 ± 0.23 0.62 ± 0.26 0.003
Serum C4 (g/L) 0.09 (0.06 to 0.17) 0.10 (0.05 to 0.17) 0.717
Serum C1q (g/L) 0.38 (0.34 to 0.43) 0.33 (0.29 to 0.40) 0.092
ANA (positive/negative) 20/3 82/8 0.837
Anti-Sm (positive/negative) 3/20 32/58 0.037
Anti-RNP (positive/negative) 4/19 34/56 0.065
Anti-dsDNA (positive/negative) 20/5 67/29 0.312
Anti-nucleosome(positive/negative) 10/6 21/25 0.246
Anti-histone (positive/negative)§ 10/5 30/19 0.703
  1. *Except where indicated otherwise, values are expressed as mean ± standard deviation or median (25th–75th percentile) as appropriate.
  2. In two patients in the LN-GMT group and nine patients in the LN-non-GMT group, ANA, anti-RNP, and anti-Sm antibodies were not detected.
  3. In three patients in the LN-non-GMT group, anti-dsDNA antibodies were not detected.
  4. In nine patients in the LN-GMT group and fifty three patients in the LN-non-GMT group, anti-nucleosome antibodies were not detected.
  5. § In 10 patients in the LN-GMT group and 50 patients in the LN-non-GMT group anti-histone antibodies were not detected.
  6. ANA = antinuclear antibodies; anti-dsDNA = anti-double-stranded DNA antibody; anti-RNP = anti-ribonucleoprotein antibody; GMT = glomerular microthrombosis; LN = lupus nephritis; SLE = systemic lupus erythematosus; SLEDAI = systemic lupus erythematosus disease activity index.