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Table 1 Demographic, clinical, and laboratory characteristics of the LN patients*

From: Antiphospholipid antibody profiles in lupus nephritis with glomerular microthrombosis: a prospective study of 124 cases

 

LN-GMT

(n = 25)

LN-non-GMT

(n = 99)

P value

Sex (male/female)

3/22

16/83

0.837

Age (years)

35 ± 14

33 ± 14

0.485

SLE duration (months)

48 (8 to 126)

19 (4 to 69.5)

0.096

LN duration (months)

19 (1 to 78)

4.5 (1–24)

0.101

SLEDAI

17 ± 6

12 ± 6

0.002

Proteinuria (g/24 hours)

3.24 (2.22 to 4.66)

2.01 (1.19 to 3.66)

0.005

Serum creatinine (μmol/L)

99.7(67.85 to 118.5)

59.6(49.08 to 82.75)

<0.001

Blood urea nitrogen (mmol/L)

11.3 (6.05 to 15)

6.4 (4.9 to 10)

0.007

Serum C3 (g/L)

0.44 ± 0.23

0.62 ± 0.26

0.003

Serum C4 (g/L)

0.09 (0.06 to 0.17)

0.10 (0.05 to 0.17)

0.717

Serum C1q (g/L)

0.38 (0.34 to 0.43)

0.33 (0.29 to 0.40)

0.092

ANA (positive/negative)

20/3

82/8

0.837

Anti-Sm (positive/negative)

3/20

32/58

0.037

Anti-RNP (positive/negative)

4/19

34/56

0.065

Anti-dsDNA (positive/negative)

20/5

67/29

0.312

Anti-nucleosome(positive/negative)

10/6

21/25

0.246

Anti-histone (positive/negative)§

10/5

30/19

0.703

  1. *Except where indicated otherwise, values are expressed as mean ± standard deviation or median (25th–75th percentile) as appropriate.
  2. In two patients in the LN-GMT group and nine patients in the LN-non-GMT group, ANA, anti-RNP, and anti-Sm antibodies were not detected.
  3. In three patients in the LN-non-GMT group, anti-dsDNA antibodies were not detected.
  4. In nine patients in the LN-GMT group and fifty three patients in the LN-non-GMT group, anti-nucleosome antibodies were not detected.
  5. § In 10 patients in the LN-GMT group and 50 patients in the LN-non-GMT group anti-histone antibodies were not detected.
  6. ANA = antinuclear antibodies; anti-dsDNA = anti-double-stranded DNA antibody; anti-RNP = anti-ribonucleoprotein antibody; GMT = glomerular microthrombosis; LN = lupus nephritis; SLE = systemic lupus erythematosus; SLEDAI = systemic lupus erythematosus disease activity index.