Degradome expression profiling in human articular cartilage

Table 3 Fold change and threshold cycle for aspartate proteases showing significant difference between OA and NOF

Gene name	Gene symbol	P value	Fold change OA/NOF	Median threshold cycle
β-Secretase 1	BACE1	0.00005	2.9	30.7
Nuclear receptor interacting protein 2	NRIP2	0.00014	3.7	33.8
Presenilin homolog 4/SPPL2B	SPPL2B	0.00028	1.9	28.1
Cathepsin D	CTSD	0.00071	3.4	24.5
Presenilin 2	PSEN2	0.00137	1.9	30.1
Nuclear receptor interacting protein 3	NRIP3	0.00170	3.7	34.6
Pepsin A	PGA3/4/5	0.00170	6.8	35.3

Fold change and median threshold cycle for all aspartate protease genes showing significant difference at P < 0.01 between osteoarthritis (OA) versus fracture to the neck of femur (NOF). P value from the Mann-Whitney U test.

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