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Table 5 Fold change and threshold cycle for metalloproteases showing significant difference between OA and NOF

From: Degradome expression profiling in human articular cartilage

Gene name

Gene symbol

P value

Fold change OA/NOF

Median threshold cycle

ADAM22

ADAM22

0.00005

6.0

32.3

ADAMTS2

ADAMTS2

0.00005

8.1

29.1

Aminopeptidase-like 1

NPEPL1

0.00005

3.7

30.2

Stromelysin 1

MMP3

0.00005

0.03

22.5

Stromelysin 3

MMP11

0.00005

81.4

31.0

MMP23A/B

MMP23A/B

0.00006

24.7

34.2

Mammalian tolloid-like 1 protein

TLL1

0.00006

4.9

31.9

ADAMTS1

ADAMTS1

0.00008

0.37

26.3

Carboxypeptidase Z

CPZ

0.00008

12.6

35.0

Procollagen C-proteinase

BMP1

0.00011

2.9

29.2

MT3-MMP

MMP16

0.00014

6.9

31.2

ADAMTS14

ADAMTS14

0.00017

11.2

33.5

ADAMTS16

ADAMTS16

0.00017

19.6

33.7

Aminopeptidase N

ANPEP

0.00017

5.3

27.2

Dihydropyrimidinase-related protein 2

DPYSL2

0.00022

2.2

25.1

Pappalysin-2

PAPPA2

0.00022

0.28

30.4

Plasma Glu-carboxypeptidase

PGCP

0.00022

2.9

29.9

Cytosol alanyl aminopeptidase

NPEPPS

0.00028

0.69

25.7

Gelatinase A

MMP2

0.00036

9.7

24.4

Leucyl aminopeptidase

LAP3

0.00045

1.6

28.9

ADAMTS9

ADAMTS9

0.00057

0.10

30.4

Gelatinase B

MMP9

0.00057

31.9

31.3

Aminopeptidase B-like 1

RNPEPL1

0.00071

2.1

29.5

Membrane dipeptidase 2

DPEP2

0.00071

5.6

35.1

NAALADASE II

NAALAD2

0.00071

3.0

35.0

PM20D2 peptidase

PM20D2

0.00071

0.36

27.6

ADAM12

ADAM12

0.00089

4.0

27.6

MMP19

MMP19

0.00089

16.5

29.8

MMP21

MMP21

0.00089

3.2

34.1

Carboxypeptidase X1

CPXM1

0.00137

36.1

31.6

ADAMTS12

ADAMTS12

0.00170

20.3

32.3

Adipocyte-enhanced binding protein 1

AEBP1

0.00170

2.2

24.6

Collagenase 3

MMP13

0.00170

26.0

27.1

ADAM9

ADAM9

0.00256

1.8

27.3

FACE-2/RCE1

FACE2

0.00256

0.80

29.6

X-Pro dipeptidase

PEPD

0.00256

2.1

31.2

Leukotriene A4 hydrolase

LTA4H

0.00313

0.51

26.7

NAALADASE like 2

NAALADL2

0.00313

3.8

31.0

Neprilysin

MME

0.00313

9.8

30.9

ADAM8

ADAM8

0.00464

2.0

34.1

Aminoacylase

ACY1

0.00464

1.6

33.2

O-Sialoglycoprotein endopeptide

OSGEP

0.00464

1.8

29.7

ADAMTS7

ADAMTS7

0.00561

15.0

34.0

Dihydroorotase

CAD

0.00561

1.4

28.1

ADAMTS6

ADAMTS6

0.00677

2.0

31.3

FACE-1/ZMPSTE24

FACE1

0.00677

1.8

30.9

Glutaminyl cyclase 2

QPCTL

0.00677

0.65

29.4

OMA1

OMA1

0.00813

0.50

27.6

Archaemetzincin-1

AMZ1

0.00974

0.58

31.4

Collagenase 1

MMP1

0.00974

0.24

30.8

Neurolysin

NLN

0.00974

1.6

30.7

  1. Fold change and median threshold cycle for all metalloprotease genes showing significant difference at P < 0.01 between osteoarthritis (OA) versus fracture to the neck of femur (NOF). P value from the Mann-Whitney U test. ADAM, a disintegrin and metalloproteinase domain; ADAMTS, a disintegrin and metalloproteinase domain with thrombospondin motifs; MMP, matrix metalloproteinase.
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Arthritis Research & Therapy

ISSN: 1478-6362

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