Skip to main content

Table 5 Fold change and threshold cycle for metalloproteases showing significant difference between OA and NOF

From: Degradome expression profiling in human articular cartilage

Gene name Gene symbol P value Fold change OA/NOF Median threshold cycle
ADAM22 ADAM22 0.00005 6.0 32.3
ADAMTS2 ADAMTS2 0.00005 8.1 29.1
Aminopeptidase-like 1 NPEPL1 0.00005 3.7 30.2
Stromelysin 1 MMP3 0.00005 0.03 22.5
Stromelysin 3 MMP11 0.00005 81.4 31.0
MMP23A/B MMP23A/B 0.00006 24.7 34.2
Mammalian tolloid-like 1 protein TLL1 0.00006 4.9 31.9
ADAMTS1 ADAMTS1 0.00008 0.37 26.3
Carboxypeptidase Z CPZ 0.00008 12.6 35.0
Procollagen C-proteinase BMP1 0.00011 2.9 29.2
MT3-MMP MMP16 0.00014 6.9 31.2
ADAMTS14 ADAMTS14 0.00017 11.2 33.5
ADAMTS16 ADAMTS16 0.00017 19.6 33.7
Aminopeptidase N ANPEP 0.00017 5.3 27.2
Dihydropyrimidinase-related protein 2 DPYSL2 0.00022 2.2 25.1
Pappalysin-2 PAPPA2 0.00022 0.28 30.4
Plasma Glu-carboxypeptidase PGCP 0.00022 2.9 29.9
Cytosol alanyl aminopeptidase NPEPPS 0.00028 0.69 25.7
Gelatinase A MMP2 0.00036 9.7 24.4
Leucyl aminopeptidase LAP3 0.00045 1.6 28.9
ADAMTS9 ADAMTS9 0.00057 0.10 30.4
Gelatinase B MMP9 0.00057 31.9 31.3
Aminopeptidase B-like 1 RNPEPL1 0.00071 2.1 29.5
Membrane dipeptidase 2 DPEP2 0.00071 5.6 35.1
NAALADASE II NAALAD2 0.00071 3.0 35.0
PM20D2 peptidase PM20D2 0.00071 0.36 27.6
ADAM12 ADAM12 0.00089 4.0 27.6
MMP19 MMP19 0.00089 16.5 29.8
MMP21 MMP21 0.00089 3.2 34.1
Carboxypeptidase X1 CPXM1 0.00137 36.1 31.6
ADAMTS12 ADAMTS12 0.00170 20.3 32.3
Adipocyte-enhanced binding protein 1 AEBP1 0.00170 2.2 24.6
Collagenase 3 MMP13 0.00170 26.0 27.1
ADAM9 ADAM9 0.00256 1.8 27.3
FACE-2/RCE1 FACE2 0.00256 0.80 29.6
X-Pro dipeptidase PEPD 0.00256 2.1 31.2
Leukotriene A4 hydrolase LTA4H 0.00313 0.51 26.7
NAALADASE like 2 NAALADL2 0.00313 3.8 31.0
Neprilysin MME 0.00313 9.8 30.9
ADAM8 ADAM8 0.00464 2.0 34.1
Aminoacylase ACY1 0.00464 1.6 33.2
O-Sialoglycoprotein endopeptide OSGEP 0.00464 1.8 29.7
ADAMTS7 ADAMTS7 0.00561 15.0 34.0
Dihydroorotase CAD 0.00561 1.4 28.1
ADAMTS6 ADAMTS6 0.00677 2.0 31.3
FACE-1/ZMPSTE24 FACE1 0.00677 1.8 30.9
Glutaminyl cyclase 2 QPCTL 0.00677 0.65 29.4
OMA1 OMA1 0.00813 0.50 27.6
Archaemetzincin-1 AMZ1 0.00974 0.58 31.4
Collagenase 1 MMP1 0.00974 0.24 30.8
Neurolysin NLN 0.00974 1.6 30.7
  1. Fold change and median threshold cycle for all metalloprotease genes showing significant difference at P < 0.01 between osteoarthritis (OA) versus fracture to the neck of femur (NOF). P value from the Mann-Whitney U test. ADAM, a disintegrin and metalloproteinase domain; ADAMTS, a disintegrin and metalloproteinase domain with thrombospondin motifs; MMP, matrix metalloproteinase.