Table 6 Fold change and threshold cycle for serine and threonine proteases significant between OA and NOF

Complement component 2

C2

0.00005

11.7

29.6

Complement factor I

CFI

0.00005

7.8

30.5

Heat shock 90 kDa protein 1 beta

HSP90AB1

0.00005

0.54

25.4

HTRA3

HTRA3

0.00005

3.3

27.3

Lysosomal carboxypeptidase A

CTSA

0.00005

2.3

25.8

Osteoblast serine protease

HTRA1

0.00005

3.0

27.7

PACE4 proprotein convertase

PCSK6

0.00005

7.5

30.8

Protein C-like

PROCL

0.00006

9.3

30.6

Rhomboid 5 homolog 1

RHBDF1

0.00006

2.0

28.3

Rhomboid 5 homolog 2

RHBDF2

0.00008

0.40

27.9

Complement factor B

CFB

0.00014

0.43

27.5

Seprase

FAP

0.00017

4.0

28.0

Proprotein convertase 7

PCSK7

0.00022

1.8

28.6

Epoxide hydrolase

EPHX1

0.00057

2.1

30.1

Presenilins-associated rhomboid like

PARL

0.00071

0.69

26.8

Rhomboid domain containing 1

RHBDD1

0.00071

0.58

26.1

Glycosylasparaginase

AGA

0.00111

1.9

29.9

Heat shock protein 90 kDa beta

HSP90B1

0.00137

0.63

24.5

HTRA4

HTRA4

0.00137

3.6

32.1

Serine carboxypeptidase 1

SCPEP1

0.00209

1.9

26.3

Complement factor D

DF

0.00313

3.8

31.0

Kallikrein hK4

KLK4

0.00382

10.3

34.4

Vitellogenic carboxypeptidase-L

CPVL

0.00382

6.2

31.6

Proprotein convertase 1

PCSK1

0.00464

0.10

30.7

Reelin

RELN

0.00464

5.6

30.0

Dipeptidyl-peptidase II

DPP7

0.00813

1.6

26.1

Lysosomal Pro-X C-peptidase

PRCP

0.00974

1.7

27.2

Proteasome catalytic subunit 1

PSMB6

0.00974

1.5

27.2