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Table 6 Fold change and threshold cycle for serine and threonine proteases significant between OA and NOF

From: Degradome expression profiling in human articular cartilage

Gene name Gene symbol P value Fold change OA/NOF Median threshold cycle
Complement component 2 C2 0.00005 11.7 29.6
Complement factor I CFI 0.00005 7.8 30.5
Heat shock 90 kDa protein 1 beta HSP90AB1 0.00005 0.54 25.4
HTRA3 HTRA3 0.00005 3.3 27.3
Lysosomal carboxypeptidase A CTSA 0.00005 2.3 25.8
Osteoblast serine protease HTRA1 0.00005 3.0 27.7
PACE4 proprotein convertase PCSK6 0.00005 7.5 30.8
Protein C-like PROCL 0.00006 9.3 30.6
Rhomboid 5 homolog 1 RHBDF1 0.00006 2.0 28.3
Rhomboid 5 homolog 2 RHBDF2 0.00008 0.40 27.9
Complement factor B CFB 0.00014 0.43 27.5
Seprase FAP 0.00017 4.0 28.0
Proprotein convertase 7 PCSK7 0.00022 1.8 28.6
Epoxide hydrolase EPHX1 0.00057 2.1 30.1
Presenilins-associated rhomboid like PARL 0.00071 0.69 26.8
Rhomboid domain containing 1 RHBDD1 0.00071 0.58 26.1
Glycosylasparaginase AGA 0.00111 1.9 29.9
Heat shock protein 90 kDa beta HSP90B1 0.00137 0.63 24.5
HTRA4 HTRA4 0.00137 3.6 32.1
Serine carboxypeptidase 1 SCPEP1 0.00209 1.9 26.3
Complement factor D DF 0.00313 3.8 31.0
Kallikrein hK4 KLK4 0.00382 10.3 34.4
Vitellogenic carboxypeptidase-L CPVL 0.00382 6.2 31.6
Proprotein convertase 1 PCSK1 0.00464 0.10 30.7
Reelin RELN 0.00464 5.6 30.0
Dipeptidyl-peptidase II DPP7 0.00813 1.6 26.1
Lysosomal Pro-X C-peptidase PRCP 0.00974 1.7 27.2
Proteasome catalytic subunit 1 PSMB6 0.00974 1.5 27.2
  1. Fold change and median threshold cycle for all serine and threonine protease genes showing significant difference at P < 0.01 between osteoarthritis (OA) versus fracture to the neck of femur (NOF). P value from the Mann-Whitney U test.