Outcome measures in inflammatory rheumatic diseases

Table 1 Pooled indices developed for rheumatoid arthritis

Name	Year	Form	Aspect	Laboratory		Symptoms		Global assessments		Joint examination		Function
Lansbury	1956	Continuous	State	ESR	MS	Fatigue	Pain*					Grip
Pooled	1977	Continuous	State	ESR	MS						TJC	Grip	Func. index
ARA remission	1981	Dichotomy	State	ESR	MS	Fatigue				SJC	TJC
Mallya	1981	Continuous	State	ESR, Hb	MS		Pain				RAI	Grip
IDA	1983	Continuous	State	ESR, Hb	MS						TJC
New IDA	1990	Continuous	State	ESR, Hb			Pain				RAI	Grip	HAQ
Stoke	1990	Continuous	State	ESR, CRP	MS						RAI, PIPs
Scott	1990	Continuous	State	ESR	MS		Pain				RAI
DAS	1990	Continuous	State	ESR				PGA^†		SJC	RAI
Paulus	1990	Dichotomy	Change	ESR	MS			PGA	DGA	SJC	TJC
RADAI^‡	1995	Continuous	State		MS		Pain	PGA	GH		TJC
DAS28	1995	Continuous	State	ESR				PGA^†		SJC	TJC
ACR response	1995	Dichotomy	Change	ESR			Pain	PGA	DGA	SJC	TJC		HAQ
EULAR response	1995	Trichotomy	Change and state	ESR				PGA		SJC	TJC
SDAI	2003	Continuous	State	CRP				PGA	DGA	SJC	TJC
CDAI	2005	Continuous	State					PGA	DGA	SJC	TJC
PASS^‡	2005	Continuous	State				Pain	PGA					HAQ
RAPID^‡	2006	Continuous	State				Pain	PGA					HAQ
ACR 'hybrid'	2007	Continuous	Change and state	ESR			Pain	PGA	DGA	SJC	TJC		HAQ

Pooled indices developed for the assessment of disease activity in rheumatoid arthritis, adapted after [5]. *Aspirine need as proxy for pain. ^†DAS and DAS28 were developed with a global General Health rating, though PGA is more broadly used than GH now. ^‡Self-assessed. ACR, American College of Rheumatology; ARA, American Rheumatism Association; CDAI, Clinical Disease Activity Index; CRP, C-reactive protein; DAS, Disease Activity Score; DGA, doctor global assessment of disease activity; ESR, erythrocyte sedimentation rate; EULAR, European League Against Rheumatism; GH, general health; Grip, grip strength; HAQ, Health Assessment Questionnaire disability index; Hb, hemoglobin level; IDA, Index of Disease Activity; MS, morning stiffness; PASS, Patient Acceptable Symptom State; PGA, patient global assessment of disease activity; PIP, proximal interphalangeal joints; RADAI, RA Disease Activity Index; RAI, Ritchie Articular Index; RAPID, Routine Assessment of Patient Index Data; SDAI, Simplified Disease Activity Index; SJC, swollen joint count; TJC, tender joint count.

ISSN: 1478-6362