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Table 3 Univariate associations between change in DXR-BMD, baseline characteristics and baseline serological biomarkers (univariate linear regression analyses)

From: Antibodies to cyclic citrullinated protein and erythrocyte sedimentation rate predict hand bone loss in patients with rheumatoid arthritis of short duration: a longitudinal study

 

One-year change in DXR-BMD (%)

Two-year change in DXR-BMD (%)

Five-year change in DXR-BMD (%)

 

B

(95% CI)

P value

B

(95% CI)

P value

B

(95% CI)

P value

Age (years)

-0.1

(-0.1 to 0.0)

0.03

-0.1

(-0.2 to 0.0)

0.002

-0.2

(-0.3 to 0.0)

0.004

Sex (female)

-0.1

(-1.4 to 1.2)

0.90

0.6

(-1.3 to 2.4

0.54

0.0

(-3.0 to 3.1)

0.98

Disease duration (years)

0.1

(-0.4 to 0.6)

0.74

0.2

(-0.5 to 0.9)

0.66

0.8

(-0.4 to 1.9)

0.18

HAQ

-1.4

(-2.2 to -0.5)

0.003

-1.9

(-3.1 to -0.7)

0.003

-2.3

(-4.5 to -0.2)

0.03

ESR (> 20 mm/h)

-2.9

(-4.0 to -1.9)

< 0.001

-4.2

(-5.7 to -2.8)

< 0.001

-6.6

(-9.0 to -4.1)

> 0.001

CRP (> 10 mg/l)

-1.6

(-2.8 to -0.3)

0.01

-3.4

(-5.1 to -1.7)

< 0.001

-3.9

(-6.8 to -1.0)

0.008

Anti-CCP (> 25 U/ml)

-2.3

(-3.4 to -1.2)

< 0.001

-3.5

(-5.1 to -2.0)

< 0.001

-6.5

(-9.0 to -4.0)

< 0.001

IgA RF (> 25 U/ml)

-0.7

(-1.9 to 0.5)

0.26

-2.6

(-4.3 to -1.0)

0.002

-5.0

(-7.6 to -2.3)

< 0.001

IgM RF(> 25 U/ml)

-1.2

(-2.3 to -0.1)

0.04

-2.8

(-4.4 to -1.3)

< 0.001

-5.5

(-8.0 to -3.0)

< 0.001

DMARD treatment

-1.6

(-2.6 to -0.5)

0.003

-2.6

(-4.3 to -0.9)

0.004

-5.0

(-7.9 to -2.2)

0.001

Prednisolone use

-1.0

(-2.2 to 0.1)

0.07

-1.9

(-3.5 to -0.4)

0.02

-3.6

(-6.2 to -1.0)

0.008

  1. Results from univariate linear regression analyses with DXR-BMD as dependent variable.
  2. Anti-CCP = antibodies to cyclic citrullinated peptide; CI = confidence interval; CRP = C-reactive protein; DMARD = disease-modifying antirheumatic drugs; DXR-BMD = hand bone mineral density estimated by digital X-ray radiogrammetry; ESR = erythrocyte sedimentation rate; HAQ = health assessment questionnaire; Ig = immunoglobulin; RA = rheumatoid arthritis; RF = rheumatoid arthritis.