Antibodies to cyclic citrullinated protein and erythrocyte sedimentation rate predict hand bone loss in patients with rheumatoid arthritis of short duration: a longitudinal study

Table 4 Independent associations between change in DXR-BMD and baseline serological biomarkers (multivariate linear regression analyses)

	One-year DXR-BMD change		Two-year DXR-BMD change		Five-year DXR-BMD change
	B (95% CI)	P value	B (95% CI)	P value	B (95% CI)	P value
Anti-CCP (> 25 U/ml)	-1.7 (-2.8 to -0.7)	0.002	-2.1 (-3.5 to -0.6)	0.006	-5.5 (-7.8 to -3.1)	< 0.001
ESR (> 20 mm/h)	-2.5 (-3.6 to -1.4)	< 0.001	-3.2 (-4.7 to -1.7)	< 0.001	-5.2 (-7.6 to -2.8)	< 0.001
CRP (> 10 mg/l)			-1.8 (-3.4 to -0.3)	0.02
DMARD treatment			-1.4 (-2.8 to -0.03)	0.05
Age (years)	-0.02 (-0.07 to 0.02)	0.3	-0.05 (-0.1 to 0.002)	0.06	-0.08 (-0.2 to 0.01)	0.09
Sex (female)	0.3 (-0.8 to 1.5)	0.6	0.1 (-0.3 to 2.8)	0.1	0.5 (-2.1 to 3.1)	0.5
Constant	0.5 (-1.9 to 3.1)	0.7	1.8 (-1.5 to 5.1)	0.3	1.8 (-3.6 to 7.2)	0.5
Adjusted R²	21.1%		29.3%		28.5%

Final models after multivariate linear regression analyses. Dependent variable: DXR-BMD change (%).
Anti-CCP = antibodies to cyclic citrullinated peptide; CI = confidence interval; CRP = C-reactive protein; DMARD = disease-modifying antirheumatic drugs; DXR-BMD = hand bone mineral density estimated by digital X-ray radiogrammetry; ESR = erythrocyte sedimentation rate.

ISSN: 1478-6362