Table 5 Cortical hand bone loss and baseline serological biomarkers (univariate logistic regression analyses)
One-year cortical hand bone loss | Two-year cortical hand bone loss | Five-year cortical hand bone loss | ||||
|---|---|---|---|---|---|---|
OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | |
Age (years) | 1.0 (1.0 to 1.0) | 0.15 | 1.0 (1.0 to 1.1) | 0.02 | 1.1 (1.0 to 1.1) | 0.01 |
Sex (female) | 1.3 (0.6 to 2.7) | 0.52 | 2.0 (0.9 to 4.5) | 0.09 | 1.0 (0.3 to 3.5) | 0.96 |
Disease duration (years) | 1.0 (0.7 to 1.3) | 0.85 | 1.1 (0.8 to 1.5) | 0.69 | 1.1 (0.7 to 1.7) | 0.66 |
HAQ | 1.9 (1.1 to 3.4) | 0.03 | 2.5 (1.3 to 5.0) | 0.01 | 1.5 (0.6 to 3.7) | 0.41 |
ESR (> 20 mm/h) | 5.2 (2.4 to 11.1) | < 0.001 | 5.5 (2.2 to 13.7) | < 0.001 | 4.6 (1.2 to 17.0) | 0.02 |
CRP (> 10 mg/l) | 1.9 (0.9 to 4.1) | 0.11 | 4.1 (1.3 to 12.3) | 0.01 | 6.0 (0.8 to 47.5) | 0.09 |
Anti-CCP (> 25 U/ml) | 2.7 (1.4 to 5.5) | 0.004 | 3.2 (1.5 to 7.0) | 0.003 | 5.1 (1.5 to 17.0) | 0.01 |
IgA RF (> 25 U/ml) | 2.6 (1.2 to 5.7) | 0.01 | 3.3 (1.3 to 8.5) | 0.01 | 2.2 (0.6 to 8.3) | 0.23 |
IgM RF (> 25 U/ml) | 1.7 (0.8 to 3.3) | 0.14 | 3.4 (1.5 to 7.8) | 0.005 | 3.8 (1.0 to 14.2) | 0.05 |
DMARD use | 2.1 (1.0 to 4.3) | 0.05 | 2.9 (1.3 to 6.3) | 0.009 | 2.5 (0.8 to 7.4) | 0.10 |
Prednisolone use | 2.3 (1.1 to 4.6) | 0.02 | 3.5 (1.5 to 8.1) | 0.004 | 4.8 (1.2 to 17.8) | 0.02 |