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Table 1 Apoptotic cell injection prevents rats from SCW-induced arthritis development

From: Apoptotic cell-mediated suppression of streptococcal cell wall-induced arthritis is associated with alteration of macrophage function and local regulatory T-cell increase: a potential cell-based therapy?

 

Acute phase (day 3)

Remission phase (days 10 and 11)

Chronic phase (days 24 to 30)

 

SCW + PBS

SCW + Apo

SCW + PBS

SCW + Apo

SCW + PBS

SCW + Apo

AI scorea

4.2 ± 0.8

2.0 ± 0.6

1.7 ± 0.7

0.5 ± 0.7

4.9 ± 3.5

1.3 ± 1.4

n

12

13

5

6

5

6

P valueb

0.041

 

0.052

 

0.030

 

Incidencec

10/12

7/13

4/5

2/6

5/5

3/6

  1. Pooled results from of three independent experiments. n, number of rats. aArticular index score presented as mean ± standard error of the mean. bCompared between streptococcal cell wall (SCW) and SCW + apoptotic cells (Apo); Mann-Whitney rank-sum test, one tail. cNumber of rats with disease among the rats of each group; the lower number of animals in the chronic phase is due to sacrifice of animals at the end of the acute phase in some experiments.
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Arthritis Research & Therapy

ISSN: 1478-6362

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