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Table 1 Apoptotic cell injection prevents rats from SCW-induced arthritis development

From: Apoptotic cell-mediated suppression of streptococcal cell wall-induced arthritis is associated with alteration of macrophage function and local regulatory T-cell increase: a potential cell-based therapy?

  Acute phase (day 3) Remission phase (days 10 and 11) Chronic phase (days 24 to 30)
  SCW + PBS SCW + Apo SCW + PBS SCW + Apo SCW + PBS SCW + Apo
AI scorea 4.2 ± 0.8 2.0 ± 0.6 1.7 ± 0.7 0.5 ± 0.7 4.9 ± 3.5 1.3 ± 1.4
n 12 13 5 6 5 6
P valueb 0.041   0.052   0.030  
Incidencec 10/12 7/13 4/5 2/6 5/5 3/6
  1. Pooled results from of three independent experiments. n, number of rats. aArticular index score presented as mean ± standard error of the mean. bCompared between streptococcal cell wall (SCW) and SCW + apoptotic cells (Apo); Mann-Whitney rank-sum test, one tail. cNumber of rats with disease among the rats of each group; the lower number of animals in the chronic phase is due to sacrifice of animals at the end of the acute phase in some experiments.