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Figure 1 | Arthritis Research & Therapy

Figure 1

From: Effect of interleukin-1β on spinal cord nociceptive transmission of normal and monoarthritic rats after disruption of glial function

Figure 1

Effect of IL-1β on C-reflex integrated activity in propentofylline-and saline-treated normal and monoarthritic rats (NS, MS, NP, and MP groups). (a) Time course of integrated C-reflex responses (% change) 10, 20 and 40 minutes after administration of saline intrathecal. (b) Time course of integrated C-reflex responses (% change) 10, 20 and 40 minutes after administration of 2 ng IL-1β intrathecally. The arrow indicates injection of saline or IL-1β at zero time. Values are means ± standard error of the mean (SEM). n = 8 rats in all groups. One-way analysis of variance (ANOVA) did not detect significant intra-group changes in either group after intrathecal saline or after IL-1β. (c) Global effect of saline intrathecally and (d) 2 ng IL-1β intrathecally on integrated C-reflex responses on the 40-minute period of testing, as revealed by percent change of area under the curves (AUCs). Values are means ± SEM. n = 8 rats in all groups. Two-way ANOVA detected that neither the propentofylline-treatment, nor the monoarthritic condition, nor the combination of propentofylline-treatment and monoarthritis affected the AUCs scores significantly or modified the response to saline intrathecally or to IL-1β intrathecally. NP = normal rats receiving intrathecal propentofylline; NS = normal rats receiving intrathecal saline; MP = monoarthritic rats receiving intrathecal propentofylline; MS = monoarthritic rats receiving intrathecal saline.

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