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Table 1 Stimulating current (mA) required for threshold activation of C-fiber evoked reflex responses in normal and monoarthritic rats treated with propentofylline (10 μg/10 μl daily) or saline (10 μl daily) during 10 days

From: Effect of interleukin-1β on spinal cord nociceptive transmission of normal and monoarthritic rats after disruption of glial function

  Saline treated Propentofylline treated
Normal 6.3 ± 0.4 8.2 ± 0.5*
Monoarthritic 3.7 ± 0.6# 7.5 ± 0.7*
  1. Values are means ± standard error the mean of stimulating current required (in mA) in the NS, MS, NP and MP groups. Two-way analysis of variance (ANOVA) identified the propentofylline treatment (P ANOVA < 0.0001, F = 25.79) and the monoarthritic condition (P = 0.0065, F = 8.64) as significant factors influencing the stimulating current required for threshold activation of the C-reflex. No propentofylline treatment × monoarthritic condition interaction was observed (P ANOVA = 0.1016, F = 2.87). Significant differences (P < 0.01) between propentofylline- and saline-treated groups are denoted by asterisks, while significant differences between monoarthritic and normal groups (P < 0.01) are indicated by the superscript # (according to the Bonferroni post hoc test). n = 8 animals for each group.
  2. NP = normal rats receiving intrathecal propentofylline; NS = normal rats receiving intrathecal saline; MP = monoarthritic rats receiving intrathecal propentofylline; MS = monoarthritic rats receiving intrathecal saline.