Analysis of skewed X-chromosome inactivation in females with rheumatoid arthritis and autoimmune thyroid diseases

Table 3 Characteristics of the patients with autoimmune thyroid diseases and skewed X-chromosome inactivation

Patient	Birth date	Disease onset	Pregnancy history	Diagnostic	Auto antibodies
90+% skewing
1	1978	22	G1, P1, A0	HT	+
2	1933	65	G11, P5, A0	HT	+
3	1969	20	G1, P1, A1	HT	+
4	1938	60	G3, P3, A0	GD	+
5	1943	45	G2, P2, A0	GD	+
6	1972	21	G2, P2, A0	HT	+
7	1964	36	G2, P2, A0	HT	+
8	1924	65	G9, P9, A0	HT	+
9	1940	59	G10, P10, A0	HT	+
10	1969	28	G4, P4, A0	GD	+
11	1979	20	G0, P0, A0	GD	-
12	1931	68	G13, P13, A0	HT	-
13	1943	59	G1, P1, A0	GD	-
14	1946	42	G2, P2, A0	GD	-
80 to 89% skewing
15	1969	23	G2, P2, A0	HT	+
16	1950	41	G3, P2, A1	GD	+
17	1980	20	G0, P0, A0	HT	+
18	1945	54	G4, P3, A0	HT	+
19	1962	36	G7, P2, A5	HT	+
20	1954	48	G3, P3, A0	GD	+
21	1984	20	G0, P0, A0	GD	+
22	1952	45	G2, P2, A0	GD	-
23	1941	58	G5, P5, A0	HT	-
24	1953	39	G2, P2, A0	GD	-
25	1947	48	G1, P1, A0	HT	-
26	1969	43	G2, P1, A1	GD	-

A = spontaneous abortions; G = number of pregnancies; GD = Graves' disease; HT = Hashimoto's thyroiditis; P = para (pregnancies carried to term and delivered).

ISSN: 1478-6362