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Figure 6 | Arthritis Research & Therapy

Figure 6

From: Flow cytometry analysis of glucocorticoid receptor expression and binding in steroid-sensitive and steroid-resistant patients with systemic lupus erythematosus

Figure 6

Correlation between GR binding and TNF-α, IL-12 and IFN-γ. Percentage inhibition of (a) TNF-α, (b) IL-12 and (c) IFN-γ cytokine secretion after PBMC incubation in RPMI with PHA plus 10-6 M dexamethasone were correlated to GR binding in (left) CD3+ and (right) CD14+ subpopulation in normal controls, SS patients and SR patients. (hollow circle represents normal group, triangle represents SS group, solid circle represents SR group). GR = glucocorticoid receptor; IFN = interferon; IL = interleukin; PBMC = peripheral blood mononuclear cells; SR = steroid-resistant; SS = steroid-sensitive; TNF = tumour necrosis factor.

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