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Figure 3 | Arthritis Research & Therapy

Figure 3

From: Cytokines in chronic rheumatic diseases: is everything lack of homeostatic balance?

Figure 3

Cytokines, hormones, and other soluble mediators controlling biology of Th17 cells leading to tissue destruction. Summary of some of the many mediators involved in Th17 differentiation, expansion, acquisition of effector function and their relationship with macrophages, which may then mediate tissue destruction. Orange arrows, enhancement; blunted black heads, inhibition; black arrows, production. AHR, aryl-hydrocarbon receptor; APO-A-1, apolipoprotein A1; MMP, matrix metalloproteinase; MΦ, macrophage; PGE2, prostaglandin E2; RORγt, retinoic acid-related orphan receptor γt; STAT, signal transducer and activator of transcription; TGFβ, T-cell growth factor beta; Treg = T cell with regulatory function.

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