From: Cytokines in chronic rheumatic diseases: is everything lack of homeostatic balance?
Process | Cytokines |
---|---|
Inflammation | IL-1/IL-1 receptor antagonist, IL-1 receptor II, soluble IL-1 receptor I, soluble IL-1 receptor II |
 | TNF/soluble TNF receptor I, soluble TNF receptor II |
 | IL-6/soluble gp130 |
 | IL-18/IL-18 binding protein |
 | IL-22/IL-22 binding protein |
 | IL-13/IL-13 receptor alpha |
 | CXCLELR+ /CXCLELR- |
 | Several proinflammatory chemokines (CXC and CC)/Duffy antigen receptor for chemokines |
 | Several proinflammatory chemokines (CC not CXC)/D6 |
 | CCL19, CCL21, CCL25, CXCL13/CCX-CKR |
 | Chemerin 9/chemerin 15 |
Immune cell responses | Th1 cells/Th2 cells |
 | Th17 cells/Th2 cells |
 | Th17 cells/T cells with regulatory function |
 | T cells with regulatory function/Th1, Th2, Th17 cells |
Tissue repair and remodeling | Transforming growth factor beta/TNF |
 | IL-1/IFNγ |
 | IL-4/IFNγ |
CD4 T-cell differentiation | IL-12/IL-4 |
 | Transforming growth factor beta/IL-6 + T-cell growth factor beta |
Tissue destruction | Osteoprotegerin/RANKL |
 | WNT/Dickkopf-1 |
Metabolism | Adiponectin/leptin, vistatin, resistin |