7ND, N-terminal natural deletion variant of monocytes chemotactic protein-1/CCL2. aIL-4 is anti-inflammatory in the context of rheumatoid arthritis synovial inflammation. By impacting on IgE production, however, IL-4 is a key cytokine in IgE-mediated inflammation. Similar considerations apply to IL-13. bIL-6 may be proinflammatory or anti-inflammatory according to the circumstances. IL-6 blockade has been shown to be clinically useful to control rheumatoid arthritis in randomized trials. cIL-10 is usually anti-inflammatory, but upon priming of monocytes with IFNα it induces proinflammatory responses.