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Table 1 Baseline characteristics of 710 patients with early rheumatoid arthritis or undifferentiated arthritis

From: Markers of B-lymphocyte activation are elevated in patients with early rheumatoid arthritis and correlated with disease activity in the ESPOIR cohort

  Patients with early RA or UA Early RA UA Univariate analysis:
P value
Multivariate analysis:
OR (95% CI), P value
   (1) (2) (1) versus (2) (1) versus (2)
  n = 710 n = 578 n = 132   
Percentage of females 76.5% 77% 74% 0.8  
Age, years 49.0 (40.0–64.0) 50.1 (42.3–65.2) 47.4 (39.5–62.4) 0.6  
ESR, mm at 1st hour 22.0 (11.2–38) 23.0 (12.0–40.1) 17.0 (10.0–32.0) 0.01 0.9 (0.9–1.0), 0.6
CRP, mg/L 9.0 (0–24.0) 9.5 (3.0–25.0) 6.0 (0–16.0) 0.002 1.0(0.9–1.1), 0.3
Positivity for anti-CCP 40.3% 47.4% 13.2% <0.0001 5.8 (3.4–10.0), 0.001
BAFF, ng/mL 0.7 (0.5–1.0) 0.7 (0.5–1.0) 0.7 (0.5–0.9) 0.5  
Beta2–microglobulin, mg/L 1.9 (1.7–2.3) 2.0 (1.7–2.4) 1.8 (1.6–2.1) 0.0002 1.5 (1.0–2.0), 0.03
Total IgG, g/L 13.5 (11.5–16.1) 13.5 (11.7–16.1) 12.9 (10.9–16.0) 0.03 0.9 (0.9–1.0), 0.4
Total IgA, g/L 2.6 (1.9–3.5) 2.8 (1.9–3.5) 2.2 (1.7–3.1) <0.0001 1.2 (0.9–1.5), 0.06
Total IgM, g/L 1.5 (1.1–2.0) 1.5 (1.1–2.0) 1.4 (1.1–1.9) 0.5  
Kappa free light chain, mg/L 13.8 (10.5–17.9) 14.3 (10.9–18.7) 11.7 (9.6–14.9) <0.0001 1.0 (0.9–1.0), 0.6
Lambda free light chain, mg/L 16.4 (12.8–21.6) 17.5 (13.2–22.5) 14.5 (11.6–18.8) <0.0001 0.9 (0.9–1.0), 0.9
Ratio of kappa to lambda 0.8 (0.3–0.99) 0.8 (0.7–1.0) 0.8 (0.7–0.9) 0.9  
  1. Results are expressed as median values (25th–75th values) or as percentages. Comparison of proportions of presence of anti-cyclic citrullinated peptide (anti-CCP) used chi-square test, and comparison of the other variables used Mann-Whitney U test. Baseline markers associated on univariate analysis with rheumatoid arthritis (RA) diagnosis were analyzed in multivariate analysis. BAFF, B-cell activating factor of the tumor necrosis factor family; CI, confidence interval; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; OR, odds ratio; UA, undifferentiated arthritis.