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Table 2 Allelic and genotypic distribution of BAFF -871T/C among patients with early rheumatoid arthritis, undifferentiated arthritis, and controls

From: Markers of B-lymphocyte activation are elevated in patients with early rheumatoid arthritis and correlated with disease activity in the ESPOIR cohort

BAFF -871T/Caia

Early RA

UA

Controls

P value

Odds ratio (95% CI)

P value

Odds ratio (95% CI)

Allele frequencies

n = 1,112

n = 260

n = 180

 

Early RA versus UA

 

Early RA versus controls

-871C (%)

603 (54)

146 (56)

90 (50)

NS

1.00 (0.77–1.30)

NS

1.18 (0.86–1.62)

-871T (%)

509 (46)

114 (44)

90 (50)

    

Genotype frequencies

n = 556

n = 130

n = 90

    

CC (%)

171 (31)

43 (33)

21 (23)

NS

1.02 (0.68–1.53)

CC versus CT and TT

NS

1.46 (0.87–2.46) CC versus CT and TT

CT (%)

261 (47)

60 (46)

48 (54)

    

TT (%)

124 (22)

27 (21)

21 (23)

NS

1.02 (0.66–1.60)

TT versus CT and CC

NS

0.94 (0.56–1.60) TT versus CT and CC

  1. Comparisons used chi-square test. BAFF, B-cell activating factor of the tumor necrosis factor family; CI, confidence interval; NS, not significant; RA, rheumatoid arthritis; UA, undifferentiated arthritis.