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Table 4 Baseline clinical and biological features in patients with early rheumatoid arthritis according to the presence of radiological erosions at enrollment

From: Markers of B-lymphocyte activation are elevated in patients with early rheumatoid arthritis and correlated with disease activity in the ESPOIR cohort

  Early erosions Absence of early erosion Univariate analysis:
P value
Multivariate analysis:
OR (95% CI), P value
  n = 138 n = 377   
Initial DAS28 5.4 (4.6–6.4) 5.2 (4.3–6.5) 0.1  
ESR, mm at 1st hour 29.5 (13.0–54.0) 20.5 (11.0–36.0) 0.002 1.1 (0.9–1.3), 0.4
CRP, mg/L 11.0 (4.0–33.1) 9.0 (0–22.0) 0.1  
IgM-RF-positive 63.7% 52.5% 0.03 0.7 (0.4–1.3), 0.2
IgA-RF-positive 64.5% 45.9% 0.0003 1.7 (1.1–2.7), 0.01
Anti-CCP-positive 61.6% 41.6% <0.0001 2.3 (1.2–4.3), 0.008
BAFF, ng/mL 0.7 (0.5–0.9) 0.8 (0.5–1.0) 0.5  
Beta2–microglobulin, mg/L 2.1 (1.7–2.4) 1.9 (1.7–2.4) 0.08  
Total IgG, g/L 13.7 (12.0–15.6) 13.3 (11.5–15.9) 0.2  
Total IgA, g/L 3.0 (2.1–3.7) 2.6 (1.9–3.4) 0.003 1.1 (0.9–1.2), 0.4
Total IgM, g/L 1.4 (1.1–2.1) 1.5 (1.1–2.1) 0.9  
Kappa free light chain, mg/L 15.3 (11.9–20.7) 13.9 (10.4–17.9) 0.007 1.0 (0.9–1.1), 0.2
Lambda free light chain, mg/L 18.3 (13.5–23.4) 16.9 (12.8–21.9) 0.1  
  1. Results are expressed as median values (25th–75th values) or as percentages. Comparison of proportions of presence of IgM-RF, IgA-RF, and anti-cyclic citrullinated peptide (anti-CCP) used chi-square test, and comparison of the other variables used Mann-Whitney U test. Baseline markers associated on univariate analysis with early erosions (radiological erosions at enrollment) were analyzed in multivariate analysis. BAFF, B-cell activating factor of the tumor necrosis factor family; CI, confidence interval; CRP, C-reactive protein; DAS28, disease activity score using 28 joint counts; ESR, erythrocyte sedimentation rate; OR, odds ratio; RF, rheumatoid factor.