Figure 1
From: Identification of progressors in osteoarthritis by combining biochemical and MRI-based markers
Marker types needed for clinical study. For a clinical study, diagnostic and prognostic markers are needed to select a population at the proper stage of osteoarthritis (OA) with a high risk of progression; and an efficacy marker is needed to evaluate the treatment effect. Supplementing the diagnostic marker, a burden of disease marker could be used to assess the total disease severity.