Upregulation of tumor necrosis factor-alpha (TNFα)-related genes in splenocytes of mice with glucose-6-phosphate isomerase (GPI)-induced arthritis. The mRNA expression levels of TNF-related genes in splenocytes of mice with GPI-induced arthritic (at day 10) relative to control splenocytes are shown. TNFα-induced adipose-related protein (TIARP) was specifically and strongly induced in splenocytes. GeneChip analysis was performed by gene expression software. ADAM17, a disintegrin and metallopeptidase domain 17; FADD, Fas (tumor necrosis factor receptor superfamily 6)-associated via death domain; GITR, glucocorticoid-induced tumor necrosis factor-related protein-D mRNA; LITAF, lipopolysaccharide-induced tumor necrosis factor-alpha factor; NFKB1, nuclear factor kappa B subunit p105; NFKB2, nuclear factor kappa B subunit p100; RIPK, receptor (tumor necrosis factor receptor superfamily)-interacting serine-threonine kinase 1 and 2; TNFAIP, tumor necrosis factor alpha-induced protein; TNFR, tumor necrosis factor receptor; TNFRSF, tumor necrosis factor receptor superfamily; TNFRSF12, WSL-1-like protein; TNFRSF22, tumor necrosis factor receptor family member SOBa mRNA; TNFSF, tumor necrosis factor (ligand) superfamily; TRAF, tumor necrosis factor receptor-associated factor; TTRAP, tumor necrosis factor receptor-associated factor and tumor necrosis factor receptor-associated protein.