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Figure 5 | Arthritis Research & Therapy

Figure 5

From: The Ras guanine nucleotide exchange factor RasGRF1 promotes matrix metalloproteinase-3 production in rheumatoid arthritis synovial tissue

Figure 5

Effect of RasGRF1 overexpression on rheumatoid arthritis fibroblast-like synoviocyte matrix metalloproteinase and cytokine production. Tissue culture supernatants from rheumatoid arthritis fibroblast-like synoviocytes transfected with empty vector or with Ras guanine nucleotide-releasing factor 1 (RasGRF1) were harvested and assessed for production of (a) matrix metalloproteinase (MMP)-1, (b) TIMP-1, (c) the ratio of TIMP-1 to MMP-1, (d) MMP-3, (e) IL-6 (n = 4 each) and (f) IL-8 (n = 3) by ELISA. *P < 0.05 compared with controls.

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Arthritis Research & Therapy

ISSN: 1478-6362

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