Figure 7

Association of RasGRF1 expression with matrix metalloproteinase production in rheumatoid arthritis synovial tissue. (a) Representative staining of rheumatoid arthritis synovial tissue with control and anti-matrix metalloproteinase (MMP)-1, MMP-3, and IL-6 antibodies (magnification × 100). (b) Correlation of Ras signaling protein expression with MMP-1 and MMP-3 production in RA synovial tissue. Pearson R values and P values are indicated. IOD, integrated optical density; RasGRF1, Ras guanine nucleotide-releasing factor 1.