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Figure 4 | Arthritis Research & Therapy

Figure 4

From: Short- and long-term effects of anti-CD20 treatment on B cell ontogeny in bone marrow of patients with rheumatoid arthritis

Figure 4

A representative plot of short-term and long-term changes of the B cell expression of CD27 and IgD on B cells in bone marrow from patients with rheumatoid arthritis receiving rituximab treatment. Lower left quadrant = immature B cells (IgD-CD27-); lower right quadrant = naïve B cells (IgD+CD27-); upper right quadrant = unswitched memory B cells (IgD+CD27+); and upper left quadrant = switched memory B cells (IgD-CD27+). (a) Rituximab-naïve patient is shown at day 0, 1 month and 3 months following treatment. (b) Rituximab-treated patient is shown at day 0, 1 month and 3 months following treatment. Arrow indicates depleted populations.

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