Short- and long-term effects of anti-CD20 treatment on B cell ontogeny in bone marrow of patients with rheumatoid arthritis

Table 3 Absolute numbers of B cells in bone marrow (per 10⁶ mononuclear cells)

	CD27^-IgD^- (Immature)		CD27^-IgD⁺ (Naïve)		CD27⁺IgD⁺ (Unswitched)		CD27⁺IgD^- (Switched)
	n = 10	n = 14	n = 10	n = 14	n = 10	n = 14	n = 10	n = 14
Baseline
Day 0	134 ± 100	282 ± 315	165 ± 158	213 ± 116	17 ± 39	29 ± 38	70 ± 48	161 ± 105
Short-term
1 month	53 ± 75 P = 0.004		4 ± 4 P = 0.002		0.5 ± 0.7 P = 0.004		40 ± 32 P = 0.01
3 months		98 ± 114 P = ns		5 ± 9 P = 0.0002		2 ± 4 P = 0.0002		39 ± 31 P = 0.0006
Post-RTX survival %	40	35	2	2	3	7	57	24

* Values are given as mean ± standard deviation.
** Statistics are calculated with paired T-test, P-values are given in comparison to day 0.
RTX = rituximab.

ISSN: 1478-6362