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Table 1 Characteristics of the study population

From: Use of methotrexate therapy is not associated with decreased prevalence of metabolic syndrome

  MetS presenta MetS absenta MetS presentb MetS absentb   
  n = 84 n = 265 n = 121 n = 228 Pvaluea Pvalueb
Demographics       
   Age, years 63.8 (± 8) 63.1 (± 7) 64.3 (± 8) 62.7 (± 7) 0.46 0.045
   Female, percentage 76 63 74 62 0.022 0.028
RA-related characteristics       
   DAS28 4.2 (± 1.3) 3.9 (± 1.4) 4.1 (± 1.3) 3.8 (± 1.4) 0.21 0.062
   ESR, mm/hour 22 (10-35) 16 (9-30) 20 (10-34) 17 (9-31) 0.059 0.33
   CRP, mg/L 11 (4-21) 6 (3-16) 8 (3-18) 6 (3-19) 0.021 0.46
   RA duration, years 7 (4-10) 7 (4-10) 7 (4-10) 7 (5-10) 0.83 0.19
   Erosion, percentage 77 83 79 83 0.20 0.36
   Number of DMARDs 1 (1-2) 1 (1-1) 1 (1-2) 1 (1-1) 0.26 0.43
   MTX current, percentage 62 60 63 59 0.71 0.46
   MTX only, percentage 39 39 41 38 0.95 0.67
   SSZ only, percentage 8 13 9 14 0.23 0.22
   HCQ only, percentage 1 4 3 4 0.31 0.55
   Combination of DMARDs, percentage 31 25 29 25 0.24 0.38
   TNF-blocking agent, percentage 11 9 11 9 0.73 0.65
   Prednisolone only, percentage 1 2 3 1 1.00 0.42
Cardiovascular risk factors       
   Current smoker, percentage 26 31 25 32 0.42 0.15
   Pack-years, years 17 (0-34) 19 (2-38) 19 (0-35) 18 (2-38) 0.23 0.75
   BMI, kg/m2 30 (± 4) 26 (± 5) 29 (± 4) 25 (± 5) < 0.001 < 0.001
   Creatinine, μmol/L 89 (± 21) 89 (± 16) 91 (± 22) 87 (± 14) 0.99 0.070
   Renal clearance, mL/minute 81 (± 24) 72 (± 19) 77 (± 23) 73 (± 19) 0.003 0.062
   Pulse, beats per minute 76 (± 11) 73 (± 9) 75 (± 11) 73 (± 9) 0.005 0.015
   Diabetes mellitus, percentage 14 3 12 3 < 0.001 0.001
   Hypothyroidism, percentage 12 2 9 2 0.001 0.003
  1. aMetabolic syndrome (MetS) according to National Cholesterol Education Program (NCEP) 2001; bMetS according to NCEP 2004. Continuous variables are presented as means (± standard deviations) in cases of normal distribution or as medians (interquartile ranges) in cases of non-normal distribution. BMI, body mass index; CRP, C-reactive protein; DAS28, disease activity score using 28 joint counts; DMARD, disease-modifying antirheumatic drug; ESR, erythrocyte sedimentation rate; HCQ, hydroxychloroquine; MTX, methotrexate; RA, rheumatoid arthritis; SSZ, sulfasalazine; TNF, tumour necrosis factor.