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Figure 14 | Arthritis Research & Therapy

Figure 14

From: Advanced glycation end products induce cell cycle arrest and proinflammatory changes in osteoarthritic fibroblast-like synovial cells

Figure 14

Hypothetical relation between AGE-induced NFκB activation and cell cycle arrest in osteoarthritic FLS. Reactive oxygen species (ROS), known to be induced by receptor for AGEs (RAGE) activation, could be a common denominator for p27Kip1 induction and NFκB activation. In turn, nuclear factor kappa B (NFκB) activation results in enhanced TNF-α expression and TNF-α-induced ROS generation, which may form a vicious loop. NFκB may also directly influence p27Kip1 expression.

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