Figure 3From: Advanced glycation end products induce cell cycle arrest and proinflammatory changes in osteoarthritic fibroblast-like synovial cellsCell proliferation and metabolic activity. Incubation of fibroblast-like synovial cells (FLS) for 16 hours with 5 mg/ml advanced glycation end products-modified (AGE)-BSA significantly reduced cell proliferation as measured by incorporation of bromodeoxyuridine (BrdU; P < 0.01, n = 6). Determination of metabolic activity in FLS with the MTT assay. AGE-BSA induced a significant decrease in metabolic activity of FLS (*P = 0.01, n = 6).Back to article page