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Figure 7 | Arthritis Research & Therapy

Figure 7

From: Suppressive effect of secretory phospholipase A2inhibitory peptide on interleukin-1β-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice

Figure 7

PIP-18 modulates joint inflammation and bone destruction more favorably than AF-2 peptide and DMARDs. Differential histologic scores (HS) of ankle joints of untreated Tg197 mice or those treated with the peptides (P-NT.II and phospholipase inhibitor from python (PIP)-18) or comparator drugs (methotrexate (Mtx); celecoxib (Cxb); infliximab (infxmab); antiflammin-2 (AF-2)) are shown. Compared with other drugs, infliximab and the peptides P-NT.II and PIP-18 significantly inhibited (a) synovitis, (b) cartilage destruction and (c) bone erosion. DMARD = disease-modifying anti-rheumatic drug.

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Arthritis Research & Therapy

ISSN: 1478-6362

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