TY - JOUR AU - Schwager, Kathrin AU - Kaspar, Manuela AU - Bootz, Frank AU - Marcolongo, Roberto AU - Paresce, Erberto AU - Neri, Dario AU - Trachsel, Eveline PY - 2009 DA - 2009/09/25 TI - Preclinical characterization of DEKAVIL (F8-IL10), a novel clinical-stage immunocytokine which inhibits the progression of collagen-induced arthritis JO - Arthritis Research & Therapy SP - R142 VL - 11 IS - 5 AB - In this article, we present a comparative immunohistochemical evaluation of four clinical-stage antibodies (L19, F16, G11 and F8) directed against splice isoforms of fibronectin and of tenascin-C for their ability to stain synovial tissue alterations in rheumatoid arthritis patients. Furthermore we have evaluated the therapeutic potential of the most promising antibody, F8, fused to the anti-inflammatory cytokine interleukin (IL) 10. SN - 1478-6354 UR - https://doi.org/10.1186/ar2814 DO - 10.1186/ar2814 ID - Schwager2009 ER -