Skip to main content

Table 2 Prediction of persistent synovitis, DMARD prescription and RA at one year in univariate logistic regression analyses

From: Positive anti-citrullinated protein antibody status and small joint arthritis are consistent predictors of chronic disease in patients with very early arthritis: results from the NOR-VEAC cohort

  Dependent variable
  Persistent synovitis
n = 98
DMARD prescription
n = 106
RA
n = 68
Baseline variables OR (95% CI) P value OR (95% CI) P value OR (95% CI) P value
Age (years) 1.02 (1.01-1.04) 0.008* 1.02 (1.00-1.04) 0.017* 1.05 (1.03-1.07) < 0.001*
Female gender 1.46 (0.91-2.33) 0.12* 1.06 (0.67-1.67) 0.80 1.12 (0.67-1.91) 0.67
68-SJC 1.08 (1.03-1.12) < 0.001* 1.14 (1.09-1.20) < 0.001* 1.15 (1.09-1.21) < 0.001*
28-TJC 1.11 (1.06-1.16) < 0.001* 1.19 (1.13-1.26) < 0.001* 1.20 (1.13-1.27) < 0.001*
ESR (mm/h) 1.00 (1.00-1.01) 0.41 1.01 (1.00-1.02) 0.09* 1.00 (0.99-1.01) 0.98
CRP (mg/l) 1.00 (0.99-1.00) 0.18* 1.00 (1.00-1.01) 0.80 1.00 (0.99-1.00) 0.23*
ACPA positivity 7.13 (3.73-13.64) < 0.001* 16.9 (7.94-35.8) < 0.001* 57.6 (24.6-134.5) < 0.001*
IgM RF positivity 5.65 (2.78-11.5) < 0.001* 11.8 (5.34-26.4) < 0.001* 28.5 (12.3-65.8) < 0.001*
Morn. stiffness >1 hour 1.74 (1.08-2.79) 0.023* 2.71 (1.68-4.38) < 0.001* 2.47 (1.40-4.37) 0.002*
HAQ (0-3) 1.61 (1.15-2.27) 0.006* 2.22 (1.57-3.14) < 0.001* 1.63 (1.11-2.39) 0.012*
Small joint arthritis§ 3.72 (2.29-6.05) < 0.001* 8.19 (4.83-13.9) < 0.001* 20.5 (8.58-48.9) < 0.001*
Ever smoker 1.19 (0.74-1.92) 0.48 1.33 (0.83-2.13) 0.24* 2.71 (1.44-5.09) 0.002*
  1. § Metacarpo-phalangeal joint, proximal interphalangeal joint, or metatarso-phalangeal joint joint swelling.*P < 0.25, variable selected for inclusion in multivariate analyses.
  2. ACPA = anti-citrullinated protein antibody; CI = confidence interval; CRP = C-reactive protein; DMARD = disease-modifying anti-rheumatic drugs; ESR = erythrocyte sedimentation rate; HAQ = Health Assessment Questionnaire; OR = odds ratio; RA = rheumatoid arthritis; RF = rheumatoid factor; SJC = swollen joint count; TJC = tender joint count.