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Table 3 Prediction of persistent synovitis, DMARD prescription and RA in final multivariate logistic regression models

From: Positive anti-citrullinated protein antibody status and small joint arthritis are consistent predictors of chronic disease in patients with very early arthritis: results from the NOR-VEAC cohort

  Dependent variable
  Persistent synovitis
n = 98
DMARD start
n = 106
RA
n = 68
Baseline variables OR (95% CI) P value OR (95% CI) P value OR (95% CI) P value
Age (years) 1.01 (0.99-1.03) 0.18 1.00 (0.98-1.02) 0.70 1.04 (1.01-1.08) 0.018
Female gender 1.20 (0.68-2.12) 0.52 0.99 (0.54-1.79) 0.97 1.24 (0.51-3.01) 0.64
ACPA positivity 4.50 (2.17-9.33) < 0.001 8.11 (3.55-18.6) < 0.001 19.3 (6.84-54.4) < 0.001
IgM RF positivity - - - - 5.02 (1.47-17.1) 0.010
Small joint arthritis§ 2.11 (1.17-3.81) 0.013 3.86 (2.02-7.37) < 0.001 3.45 (1.21-9.90) 0.021
HAQ 1.73 (1.12-2.68) 0.014 1.75 (1.13-2.74) 0.012 - -
28-TJC - - 1.06 (1.00-1.13) 0.064 1.09 (1.02-1.16) 0.012
CRP (mg/l) 0.99 (0.98-1.00) 0.042 - - - -
Constant 0.069 - 0.075 - 0.003 -
  1. § Metacarpo-phalangeal joint, proximal interphalangeal joint, or metatarso-phalangeal joint joint swelling.
  2. ACPA = anti-citrullinated protein antibody; CI = confidence interval; CRP = C-reactive protein; DMARD = disease-modifying anti-rheumatic drugs; HAQ = Health Assessment Questionnaire; OR = odds ratio; RA = rheumatoid arthritis; RF = rheumatoid factor; TJC = tender joint count.