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Table 2 Plasma cytokine levels of healthy controls and scleroderma patients

From: Plasma cytokine profiles in systemic sclerosis: associations with autoantibody subsets and clinical manifestations

 

Healthy controls (n = 216)

Scleroderma patients (n = 444)

Pvalue

 

pg/ml

log n cytokine

pg/ml

log n cytokine

Unpaired ttest

Adjusted for age and gender

TNFα

8.9 ± 0.5

1.90 ± 0.06

14.1 ± 0.7

2.27 ± 0.05

<0.0001

<0.0001

IL1β

7.0 ± 1.2

0.36 ± 0.11

5.8 ± 0.8

0.38 ± 0.07

NS

NS

IL-6

5.2 ± 0.8

0.55 ± 0.11

9.7 ± 1.2

1.24 ± 0.07

<0.0001

<0.0001

IL-8

77.7 ± 20.1

1.32 ± 0.15

84.3 ± 13.8

1.58 ± 0.11

NS

NS

IL-2

2.8 ± 0.7

0.05 ± 0.08

2.4 ± 0.4

0.02 ± 0.05

NS

NS

IFNγ

2.9 ± 0.5

- 0.17 ± 0.08

8.2 ± 4.6

- 0.06 ± 0.06

NS

0.05

IL-12p70

16.2 ± 4.3

0.66 ± 0.12

53.2 ± 12.8

0.71 ± 0.09

NS

NS

IL-4

5.1 ± 0.8

0.38 ± 0.11

5.4 ± 1.2

0.32 ± 0.07

NS

NS

IL-5

1.2 ± 0.2

- 0.27 ± 0.05

11.1 ± 5.1

- 0.14 ± 0.06

NS

NS

IL-13

24.6 ± 1.7

2.97 ± 0.06

51.5 ± 12.0

3.12 ± 0.05

0.05

NS

IL-10

18.5 ± 11.6

0.62 ± 0.10

30.6 ± 10.0

0.83 ± 0.08

NS

0.07

IL-17

1.9 ± 0.2

0.04 ± 0.08

1.2 ± 0.1

- 0.22 ± 0.04

0.0009

0.0005

IL-23

4.7 ± 1.1

0.46 ± 0.12

3.7 ± 0.5

0.18 ± 0.07

0.04

0.014

  1. Plasma cytokine levels are presented as both absolute levels (pg/ml) as well as natural log-transformed (log n cytokine) to normalize the data for analysis. Data presented as the mean ± standard error of the mean. P value determined either by unpaired t test or by logistic regression controlling for age and gender; NS, not significant with P > 0.05.
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Arthritis Research & Therapy

ISSN: 1478-6362

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