Plasma cytokine profiles in systemic sclerosis: associations with autoantibody subsets and clinical manifestations

Table 3 Plasma cytokine associations with clinical involvement of scleroderma

	Present	Absent	Unknown	Cytokine	Odds ratio	95% confidence interval	Pvalue
Interstitial lung disease	120	196	128	IL-6	1.33	1.08 to 1.62	0.006
Pulmonary hypertension	58	255	131	IL-6	1.31	1.04 to 1.67	0.02
				IL-13	1.42	1.04 to 1.94	0.03
SSc renal crisis	20	294	130	TNFα	2.22	1.11 to 4.45	0.02
Sjogren's syndrome	118	199	127	IL-8	0.89	0.81 to 0.99	0.03
				IL-1β	0.75	0.63 to 0.88	0.0006
Myositis	17	297	130	None
Primary biliary cirrhosis	5	309	140	IL-17	3.46	1.35 to 8.9	0.01

Cytokine levels were normalized using log_ntransformation. Logistic regression was used to compare cytokine levels to control subjects for gender and age and odd ratios reflect each cytokine as a continuous variable.

ISSN: 1478-6362