Figure 7
From: Melanocortin peptides inhibit urate crystal-induced activation of phagocytic cells
Effects of alpha-melanocyte-stimulating hormone (α-MSH) and (CKPV)2 on the priming activity of supernatants from monosodium urate-stimulated monocytes (SMMs) on chemiluminescence (CL) production by neutrophils. Neutrophils were pretreated with or without the peptides (10-6 M) for 18 hours and then were incubated with RPMI or SMMs for 30 minutes, and CL production in response to monosodium urate (3 mg/mL) was measured. Results are expressed as peak CL values in millivolts. °P < 0.01 versus RPMI+RPMI; *P < 0.01 versus RPMI+SMMs.