The ITGAVrs3738919 variant and susceptibility to rheumatoid arthritis in four Caucasian sample sets

Table 1 Allele and genotype distribution of rs3738919

Cohort	Case, number (frequency)	Control, number (frequency)	Pvalue	OR (95% CI)
New Zealand
Minor allele	501 (0.339)	408 (0.369)	0.11	0.88 (0.75-1.03)
Genotype 1,1	326 (0.38)	210 (0.38)	-	1
1,2	327 (0.44)	278 (0.50)	0.021	0.76 (0.60-0.96)
2,2	87 (0.12)	65 (0.12)	0.43	0.86 (0.60-1.24)
HWE	0.72	0.061
Dominant			0.028
Additive			0.10
Recessive			0.99
Oxford, UK
Minor allele	506 (0.355)	329 (0.319)	0.068	1.17 (0.99-1.39)
Genotype 1,1	300 (0.42)	235 (0.46)	-	1
1,2	319 (0.45)	231 (0.45)	0.52	1.08 (0.85-1.38)
2,2	93 (0.13)	49 (0.10)	0.044	1.49 (1.01-2.19)
HWE	0.60	0.47
Dominant			0.22
Additive			0.069
Recessive			0.055
WTCCC
Minor allele	1,141 (0.344)	1,928 (0.365)	0.044	0.91 (0.83-1.00)
Genotype 1,1	708 (0.43)	1,044 (0.40)	-	1
1,2	761 (0.46)	1,262 (0.48)	0.079	0.89 (0.78-1.01)
2,2	190 (0.11)	333 (0.13)	0.094	0.84 (0.69-1.03)
HWE	0.50	0.11
Dominant			0.043
Additive			0.041
Recessive			0.26
Jacq et al. [20]
Minor allele	292 (0.352)	343 (0.413)	0.01	0.77 (0.63-0.94)
Genotype 1,1	166 (0.40)	148 (0.36)	-	1
1,2	206 (0.50)	191 (0.46)	0.80	0.96 (0.71-1.29)
2,2	43 (0.10)	76 (0.18)	0.002	0.50 (0.33-0.78)
HWE	0.0718	0.30
Dominant			0.20
Additive			0.0096
Recessive			0.0011
Combined
Minor allele	2,440 (0.346)	3,008 (0.365)	0.014	0.92 (0.86-0.98)
Genotype 1,1	1,500 (0.43)	1,637 (0.40)	-	1
1,2	1,614 (0.46)	1,966 (0.48)	0.028	0.90 (0.81-0.99)
2,2	413 (0.12)	523 (0.13)	0.046	0.86 (0.74-1.00)
HWE	0.51	0.083
Dominant			0.011
Additive			0.013
Recessive			0.20

CI, confidence interval; HWE, Hardy-Weinberg equilibrium P value; OR, odds ratio; WTCCC, Wellcome Trust Case Control Consortium.

ISSN: 1478-6362