Are CD4+CD25-Foxp3+cells in untreated new-onset lupus patients regulatory T cells?

Table 1 Expressions of GITR, CTLA-4, and CCR4 on CD4⁺ subpopulations from untreated new-onset lupus patients and healthy controls

Subgroups	GITR, %		CTLA-4, %		CCR4, %
	UNOL	HC	UNOL	HC	UNOL	HC
CD4⁺ CD25^- Foxp3⁺	4.41 ± 0.67	5.13 ± 1.23	39.78 ± 1.67	53.12 ± 4.29	35.76 ± 2.53	34.33 ± 2.90
CD4⁺ CD25⁺ Foxp3⁺	22.49 ± 1.75	29.88 ± 3.24	73.89 ± 2.76	81.66 ± 4.85	49.44 ± 2.75	56.91 ± 3.17
CD4⁺ CD25⁺ Foxp3^-	6.52 ± 0.89	4.89 ± 1.32	33.57 ± 2.98	40.59 ± 5.55	31.99 ± 3.76	32.23 ± 5.54
CD4⁺ CD25^- Foxp3^-	5.35 ± 0.88	11.77 ± 2.75	15.05 ± 2.24	16.06 ± 4.25	13.58 ± 2.57	10.11 ± 3.63

Values are presented as mean ± standard deviation. CCR4, chemokine receptor 4; CTLA-4: Cytotoxic T lymphocyte-associated antigen 4; GITR: glucocorticoid-induced tumor necrosis factor receptor; HC: healthy controls; UNOL: patients with untreated new-onset lupus.

ISSN: 1478-6362