Are CD4+CD25-Foxp3+cells in untreated new-onset lupus patients regulatory T cells?

Table 2 Expressions of IFN-γ, IL-4, IL-2, and IL-17 on CD4⁺ subpopulations from untreated new-onset lupus patients and healthy controls

	IFN-γ, %		IL-4, %		IL-2, %		IL-17, %
	UNOL	HC	UNOL	HC	UNOL	HC	UNOL	HC
CD4⁺ CD25^- Foxp3⁺	7.56 ± 1.23	5.79 ± 1.05	2.97 ± 0.83	2.02 ± 0.83	3.59 ± 1.95	5.09 ± 1.95	4.61 ± 1.54	1.54 ± 1.02
CD4⁺ CD25⁺ Foxp3⁺	0.72 ± 0.34	1.22 ± 0.58	0.39 ± 0.37	0.88 ± 0.37	0.73 ± 0.49	0.22 ± 0.49	0.38 ± 0.32	0.08 ± 0.06
CD4⁺ CD25⁺ Foxp3^-	16.43 ± 3.51	16.81 ± 3.97	13.15 ± 2.99	12.94 ± 2.99	20.41 ± 4.91	19.91 ± 4.91	5.58 ± 1.51	2.37 ± 1.51
CD4⁺ CD25^- Foxp3^-	3.54 ± 1.05	5.92 ± 1.57	0.94 ± 0.56	0.66 ± 0.56	2.92 ± 1.42	8.22 ± 1.42	0.49 ± 0.35	0.67 ± 0.42

Values are presented as mean ± standard deviation. HC: healthy controls; IFN-γ: interferon-gamma; IL: interleukin; UNOL: patients with untreated new-onset lupus.

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