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Table 1 Clinical characteristics of myositis patients with calcinosis samples and the methods used to characterize the specimens

From: Microstructure and mineral composition of dystrophic calcification associated with the idiopathic inflammatory myopathies

Sample Study performed Location Diagnosis Age at surgical removal Race Gender Duration of myositis Estimated calcinosis duration Medications at time of surgical removal
Calc1 FTIR-RM qBSE SEM/SDD-EDS PLM Elbow JDM 15.5 years Hispanic Male 5.8 years 2-3 months Methylprednisolone, cyclosporine, azathioprine, alendronate, ibuprofen
Calc2 FTIR-RM qBSE SEM/SDD-EDS PLM, μCT Toe JPM 5.4 years Black Male 2 years 12 months Prednisone, cyclosporine, rofecoxib, calcium
Calc3 qBSE PLM Biceps JDM 11.9 years Caucasian Female 4.5 years 9 months Prednisone, methotrexate, hydroxychloroquine, probenecid
Calc4 qBSE PLM Hamstring JPM 16.8 years Caucasian Female 4.9 years > 3 years Alendronate, celecoxib, diltiazem
Calc6 qBSE PLM Right buttock DM 56 years Korean Female 4.9 years 6 months Prednisone
Calc7 * FTIR-RM XRD, μCT PLM Elbow and finger DM 50 years Caucasian Female 12 years Unknown Prednisone, methotrexate, alendronate, valdecoxib
Calc8 FTIR-RM XRD, μCT PLM Shoulder JDM 49 years Caucasian Female 30 years 27 years Nifedipine
Calc10 FTIR-RM PLM Thigh JDM 12 years Caucasian Female 4 years 3 months Prednisone, methotrexate, myocophenolate mofetil, alendronate, colchicine, folic acid
  1. Specimens Calc5 and Calc9 were not included in this study. *post-mortem sample DM = dermatomyositis; FTIR-RM = Fourier Transform Infrared microspectroscopy in reflectance mode; JDM = juvenile dermatomyositis; JPM = juvenile polymyositis; PLM = polarized light microscopy; qBSE = quantitative backscattered electron; SEM/SDD-EDS = scanning electron microscopy/silicon drift detector energy dispersive X-ray spectrometry; μCT = X-ray micro-computed tomography; XRD = X-ray diffraction.