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Figure 1 | Arthritis Research & Therapy

Figure 1

From: Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor, matrix metalloproteinase-1, and matrix metalloproteinase-13 expression in fibroblast-like synoviocytes more than proinflammatory mediators

Figure 1

Comparative effect of adiponectin and interleukin (IL)-1β on the production of IL-6, IL-8, and prostaglandin E2 (PGE2) in rheumatoid arthritis fibroblast-like synoviocytes. IL-1β at 1 ng/mL stimulates the production of (a) IL-6, (b) IL-8, and (c) PGE2 more than 10 μg/mL adiponectin. (d) The expression of cycloxygenase-2 (COX-2) increased only in the presence of IL-1β in proportion to the level of PGE2. The data shown are representative of three independent experiments, and similar results were obtained from all three. Values are expressed as mean ± standard error of the mean. * P < 0.05, ** P < 0.01 versus nontreated group. ns, not significant.

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