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Figure 5 | Arthritis Research & Therapy

Figure 5

From: Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor, matrix metalloproteinase-1, and matrix metalloproteinase-13 expression in fibroblast-like synoviocytes more than proinflammatory mediators

Figure 5

Testing possible adiponectin-mediated factors that may stimulate matrix metalloproteinase (MMP) expression in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLSs). (a) Adiponectin-mediated interleukin (IL)-6 and IL-8 may stimulate MMP expression, but the levels of MMPs at 6 hours of stimulation are very low compared with that stimulated by IL-1β, which did not stimulate MMP expression in RA FLSs. (b) Recombinant adiponectin protein contaminated with lipopolysacchride (LPS) could stimulate MMP expression; however, LPS at 1 μg/mL did not strongly stimulate the expression of these proteins compared with adiponectin at 10 μg/mL. The data shown are representative of two independent experiments, which were performed in duplicate. Similar results were obtained from the two experiments.

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