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Figure 2 | Arthritis Research & Therapy

Figure 2

From: Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1β-induced NF-κB-mediated inflammation and apoptosis

Figure 2

Effects of resveratrol and curcumin and IL-1β on the viability and proliferation of primary chondrocytes in vitro. To evaluate the effect of curcumin, resveratrol and/or IL-1β-induced cytotoxicity, primary chondrocytes were treated with 10 ng/ml IL-1β, 50 μM resveratrol, 50 μM curcumin, 50 μM resveratrol and 50 μM curcumin; alternatively they were pre-treated with 50 μM resveratrol, 50 μM curcumin, 50 μM resveratrol and 50 μM curcumin for 4 hours and then co-treated with 10 ng/ml IL-1β, or were left untreated and evaluated after 24 hours using the MTT method. In cells treated with either curcumin, resveratrol or a combination of both, the cytotoxic effects induced by IL-1β were significantly decreased (*) and cell viability was comparable with control cultures.

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