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Figure 6 | Arthritis Research & Therapy

Figure 6

From: Effect of small interference RNA (siRNA) for ADAMTS5on intervertebral disc degeneration in the rabbit anular needle-puncture model

Figure 6

Magnetic resonance imaging (MRI) assessment 8 weeks after small interfering RNA (siRNA) injection in the rabbit anular puncture model of disc degeneration. An observer blinded to the study assessed the MRIs by using the modified Thompson scale, based on changes in the degree and area of signal intensity from grades 1 to 4. After assessment of the MRI grades, a significantly lower (better) MRI grade in the ADAMTS5 siRNA-injected discs was observed compared with the control siRNA-injected discs (P = 0.02, Mann-Whitney test).

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