Skip to main content


Figure 8 | Arthritis Research & Therapy

Figure 8

From: Effect of small interference RNA (siRNA) for ADAMTS5on intervertebral disc degeneration in the rabbit anular needle-puncture model

Figure 8

Histologic assessment after ADAMTS5 small interfering RNA (siRNA) or control siRNA injection in the rabbit anular puncture model of disc degeneration. In ADAMTS5 siRNA-injected discs, the anulus fibrosus (AF) and the border between the AF and nucleus pulposus (NP) showed a tendency to have a lower (better) histologic score than the control siRNA-injected discs (Mann-Whitney test; P < 0.1). In the NP, the cellularity, matrix, and total grading score (SUM) were significantly better in the ADAMTS5 siRNA-injected discs than in the control siRNA-injected discs (Mann-Whitney test; P < 0.05).

Back to article page