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Table 1 Antibiotic therapy for early Borrelia burgdorferi infection

From: Treatment of Lyme borreliosis

Early manifestations (days to a few weeks after the tick bite)
General symptoms Influenza-like disease • Amoxicillin 50 mg/kg/day in three divided doses (maximum dose 1,500 mg/day)
   • Doxycycline 4 mg/kg/day in two divided doses (maximum 200 mg/day; after 8 years of age)
   for 14 days
Skin Erythema migrans • Amoxicillin 50 mg/kg/day in three divided doses (maximum dose 1,500 mg/day)
   • Cefuroxime axetil 20 to 30 mg/kg/day in two divided doses (maximum dose 1,000 mg/day)
   • Doxycycline 4 mg/kg/day in two divided doses (maximum 200 mg/day; after 8 years of age)
   for 14 days or
  Lymphocytoma for 28 days
Neurologic disease Lymphocytic meningitis • Intravenous ceftriaxone 50 mg/kg/day in one dose (maximum dose 2,000 mg/day)
  Cranial neuritis, in particular facial nerve • Intravenous cefotaxime 200 mg/kg/day in three divided doses (maximum dose 6,000 mg/day)
Cardiac disease Myopericarditis • Intravenous penicillin G 0.5 million U/kg/day in four to six divided doses (maximum 20 million U/day)
   for 14 days
   • Doxycycline 4 mg/kg/day in two divided doses (maximum 200 mg/day; after 8 years of age)
   for 14 to 28 days
Eye Conjunctivitis (in case of influenza-like disease) • Amoxicillin 50 mg/kg/day in three divided doses (maximum dose 1,500 mg/day)
Joint, muscle Arthralgia • Doxycycline 4 mg/kg/day in two divided doses (maximum 200 mg/day; after 8 years of age)
   for 14 days