Table 2 Therapy for late stages of Borrelia burgdorferi infection or inflammation
Late stages of Lyme disease (months to years after the tick bite) | ||
|---|---|---|
Skin | Acrodermatitis chronica atrophicans | • Intravenous cefotaxime 50 mg/kg/day in one dose (maximum dose 2,000 mg/day) |
Neurologic disease | Meningoradiculoneuritis | • Intravenous cefotaxime 200 mg/kg/day in three divided doses (maximum dose 6,000 mg/day) |
|  | Encephalomyelitis | • Intravenous penicillin G 0.5 million U/kg/day in four to six divided doses (maximum 20 million U/day) |
Heart | Cardiomyopathy | for 14 days |
Eye | Uveitis, keratitis | • Doxycycline 4 mg/kg/day in two divided doses (maximum 200 mg/day; after 8 years of age) |
| Â | Â | for 28 days |
Joint, muscle | Episodic or chronic oligoarthritis | For arthritis, add a nonsteroidal anti-inflammatory drug |