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Table 2 Therapy for late stages of Borrelia burgdorferi infection or inflammation

From: Treatment of Lyme borreliosis

Late stages of Lyme disease (months to years after the tick bite)
Skin Acrodermatitis chronica atrophicans • Intravenous cefotaxime 50 mg/kg/day in one dose (maximum dose 2,000 mg/day)
Neurologic disease Meningoradiculoneuritis • Intravenous cefotaxime 200 mg/kg/day in three divided doses (maximum dose 6,000 mg/day)
  Encephalomyelitis • Intravenous penicillin G 0.5 million U/kg/day in four to six divided doses (maximum 20 million U/day)
Heart Cardiomyopathy for 14 days
Eye Uveitis, keratitis • Doxycycline 4 mg/kg/day in two divided doses (maximum 200 mg/day; after 8 years of age)
   for 28 days
Joint, muscle Episodic or chronic oligoarthritis For arthritis, add a nonsteroidal anti-inflammatory drug