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Table 2 Effects of co-immunization with altered peptide ligands on the development of arthritis

From: Altered peptide ligands inhibit arthritis induced by glucose-6-phosphate isomerase peptide

Co-immunization Incidence Day of onset Maximum severity
None 8/8 10 ± 0.0 10.9 ± 1.4
APL 6 8/8 10 ± 0.0 7.5 ± 2.0*
APL 7 6/8 10 ± 0.0 7.8 ± 1.7*
APL 12 7/8 10.3 ± 0.8 5.0 ± 1.2**
APL 13 3/8† 10 ± 0.0 4.0 ± 0.0**
  1. Mice were co-immunized with 10 μg glucose-6-phosphate isomerase hGPI325--339and 50 μg indicated antigen. Data presented as incidence or mean ± standard deviation. P < 0.05 (Fisher's exact test). *P < 0.005, **P < 0.001 (Mann--Whitney U test).