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Table 2 Effects of co-immunization with altered peptide ligands on the development of arthritis

From: Altered peptide ligands inhibit arthritis induced by glucose-6-phosphate isomerase peptide

Co-immunization

Incidence

Day of onset

Maximum severity

None

8/8

10 ± 0.0

10.9 ± 1.4

APL 6

8/8

10 ± 0.0

7.5 ± 2.0*

APL 7

6/8

10 ± 0.0

7.8 ± 1.7*

APL 12

7/8

10.3 ± 0.8

5.0 ± 1.2**

APL 13

3/8†

10 ± 0.0

4.0 ± 0.0**

  1. Mice were co-immunized with 10 μg glucose-6-phosphate isomerase hGPI325--339and 50 μg indicated antigen. Data presented as incidence or mean ± standard deviation. †P < 0.05 (Fisher's exact test). *P < 0.005, **P < 0.001 (Mann--Whitney U test).
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Arthritis Research & Therapy

ISSN: 1478-6362

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